. Author manuscript; available in PMC: 2011 Dec 19.

Published in final edited form as: Biochemistry. 2011 Sep 7;50(39):8374–8382. doi: 10.1021/bi2009079

Table 1.

Protein Transduction Properties of RNase A and CPPs

	RNase A	R₉	TAT

Total residues	124	9	11
Arginine residues	4	9	6
Lysine residues	10	0	2
Net charge	+4	+9	+8
Cell-surface receptors	Heparan sulfate proteoglycans Chondroitin sulfate proteoglycans Sialic acid-containing glycoproteins	Heparan sulfate proteoglycans Chondroitin sulfate proteoglycans
Cell-types targeted	All cell types	All cell types
Mechanism of internalization	Clathrin-mediated endocytosis Macropinocytosis	Clathrin-mediated endocytosis Caveolar-mediated endocytosis Macropinocytosis Possible non-endocytic mechanism