Figure 2. Effect of farnesol on intracellular glutathione levels and viability in CA and cdr1 in the presence and absence of exogenous glutathione following 3 h and 18 h exposure to increasing farnesol concentrations.

(A) Significant decrease in glutathione levels in CA proportional to farnesol concentration and time of exposure with minimal decrease in glutathione in cdr1. Exogenous glutathione (G) inhibited drop in intracellular levels in both strains. Error bars indicate the standard errors of the means. (B) Farnesol concentration and exposure time-dependent killing of C. albicans with cdr1 exhibiting decreased susceptibility. However, no killing was observed upon supplementation with exogenous glutathione (G). Error bars indicate the standard errors of the means.