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. 2011 Dec 19;6(12):e29034. doi: 10.1371/journal.pone.0029034

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Algar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) GUSB expression values were obtained from a 50 ng equivalent of total RNA. Quantitative analysis of CDKN1C expression. (b) CDKN1C expression in the blood from 12 unaffected individuals (diamonds), five BWS cases with loss of methylation at IC2 and no deletion (squares), and individuals with deletion of the maternal IC2 (triangles). The Mann Whitney non-parametric U test was used to derive the P values shown. Statistically significant P values were obtained for the population differences in CDKN1C expression between unaffected controls and cases with loss of methylation and KCNQ1/IC2 deletion.