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. 2011 Dec 19;6(12):e29304. doi: 10.1371/journal.pone.0029304

Figure 4. Deletion of KSR1 in mark2-/- mice reverts insulin sensitivity, but not glucose tolerance.

Figure 4

A. Insulin tolerance tests (ITT) were performed on WT, mark2-/ -, ksr1-/- and DKO mice. Results shown are normalized to initial blood glucose levels. B. Glucose tolerance tests (GTT) were performed on WT, mark2-/ -, ksr1-/- and DKO mice. Results shown are normalized to initial blood glucose levels. C. Serum insulin levels before GTT (0 min) and 15 min after an IP injection of glucose (15 min). The number of mice analyzed under each condition is indicated above each bar. D. Insulin stimulated ERK activation in BAT. Mice were injected with insulin then sacrificed 15 min later. BAT was excised, lysed, and western blot performed using pERK and ERK specific antibodies. *p<0.05, ***p<0.001.