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. 2011 Dec 19;6(12):e29144. doi: 10.1371/journal.pone.0029144

Table 4. Condensed chromatin area and chromatin textural contrast in 1.0 mM VPA- treated HeLa cells.

Treatment Sc% AAR
time (h) Drug X S Md X S Md
1 Untreated control 69.17 10.13 70.77a 1.27 0.09 1.26a
VPA 44.53 22.93 45.57b 1.36 0.13 1.34b
2 Untreated control 68.53 14.52 70.65a 1.25 0.08 1.24a
VPA 23.96 18.88 20.67b 1.50 0.16 1.48b
4 Untreated control 60.15 13.17 60.86a 1.36 0.14 1.35a
VPA 53.20 17.86 56.93b 1.34 0.12 1.32a
24 Untreated control 57.75 14.84 59.91a 1.35 0.14 1.32a
VPA 34.18 22.18 35.55b 1.44 0.15 1.42b
a,b

, The median values of the VPA groups and their respective control for each treatment time differ significantly at the P 0.05 level (Mann-Whitney test); AAR, average absorption ratio; Md, median; S, standard deviation; Sc %, relative condensed chromatin area; VPA, valproic acid; X, arithmetic mean; n, 200