Table 3. Main effects of genotypes on lung cancer risk stratified by smoking.

Polymorphism	Genotype	Smoker		Non Smoker
		Case/Control (n,%)	OR (95% C.I.),p value*	Case/Control (n,%)	OR (95% C.I.),p value*
CYP1A1 * 2A	TT	44(33.3)/57(41.0)	1.0	11(19.6)/65(28.6)	1.0
	TC	74(56.1)/61(43.9)	1.45(0.84–2.50),0.17	29(51.8)/63(41.7)	2.88(1.22–6.81),0.016
	CC	14(10.6)/21(15.1)	0.83(0.36–1.91),0.66	16(28.6)/23(15.2)	4.35(1.47–12.84),0.008#
CYP1A1 * 2C	AA	86(65.2)/93(66.9)	1.0	36(64.3)/113(74.8)	1.0
	AG	40(30.3)/40(28.8)	1.14(0.65–2.02),0.63	16(28.6)/37(24.5)	1.53(0.67–3.48),0.30
	GG	6(4.5)/6(4.3)	1.71(0.43–6.74),0.43	4(7.1)/1(0.7)	11.81(1.24–111.98),0.03
EPHX1 Tyr113His	TT	60(45.5)/41(29.5)	1.0	22(39.3)/53(35.1)	1.0
	TC	35(26.5)/71(51.1)	0.34(0.18–0.63),0.001#	16(28.6)/62(41.1)	0.62(0.25–1.54),0.30
	CC	37(28.0)/27(19.4)	1.14(0.57–2.29),0.69	18(32.1)/36(23.8)	1.03(0.41–2.56),0.94
EPHX1 His139Arg	AA	80(60.6)/103(74.1)	1.0	41(73.2)/109(72.2)	1.0
	AG	48(36.4)/32(23.0)	1.92(1.07–3.45),0.02	11(19.6)/38(25.2)	0.98(0.41–2.36),0.98
	GG	4(3.0)/4(2.9)	1.39(0.31–6.25),0.66	4(7.1)/4(2.6)	4.25(0.54–33.15),0.16
GSTM1	WildType	91(68.9)/86(61.9)	1.0	31(55.4)/91(60.3)	1.0
	Null	41(31.1)/53(38.1)	0.87(0.51–1.48),0.62	25(44.6)/60(39.7)	1.25(0.61–2.54),0.53
GSTT1	WildType	106(80.3)/104(74.8)	1.0	49(87.5)/113(74.8)	1.0
	Null	26(19.7)/35(25.2)	0.75(0.40–1.41),0.37	7(12.5)/38(25.2)	0.48(0.19–1.20),0.11
GSTP1	AA	69(52.3)/77(55.4)	1.0	33(58.9)/102(67.5)	1.0
	AG	54(40.9)/55(39.6)	1.35(0.77–2.36),0.29	23(41.1)/41(27.2)	2.40(1.15–5.03),0.01#
	GG	9(6.8)/7(5.0)	1.49(0.49–4.56),0.47	0/8(5.3)	NA
SULT1A1	GG	84 (63.6)/69 (49.6)	1.0	39(69.6)/84(55.6)	1.0
	GA	35 (26.5)/58 (41.7)	0.45(0.25–0.80),0.007#	15(26.8)/58(38.4)	0.54(0.24–1.19),0.13
	AA	13 (9.8)/12 (8.6)	1.11(0.45–2.74),0.81	2(3.6)/9(6.0)	0.48(0.09–2.54),0.39

*p values adjusted for tobacco chewing, betel quid chewing and alcohol consumption.

^#Significant after p-value adjustment for multiple comparision (Sidak correction).