. 2011 Dec 19;6(12):e29431. doi: 10.1371/journal.pone.0029431

Table 4. Results of MDR analysis.

	No. of Locus	Model	p value (χ² test)	TBA	p-value^*	CVC	p-value^*
Total Data Set
	1st order	Smk	p < 0.0001	0.6114	<0.001	10	0.391
	2^nd order	Smk Ex3	p < 0.0001	0.6407	<0.001	10	0.391
	3^rd order	Smk Ex3 Ex4	p < 0.0001	0.6497	<0.001	10	0.391
	4^th order**	Smk Ex3 Ex4 SULT	p < 0.0001	0.6503	<0.001	10	0.391
Smokers
	1st order	Ex3	p < 0.0001	0.6228	0.012	10	0.402
	2^nd order	Tbc Ex3	p < 0.0001	0.6105	<0.02	9	0.623
	3^rd order**	Tbc Ex3 SULT	p < 0.0001	0.6436	<0.001	10	0.402
	4^th order	Tbc Alc Ex3 SULT	p < 0.0001	0.6268	<0.008	7	0.846
Non Smokers
	1st order	2A	p = 0.0019	0.6170	0.09	10	0.372
	2^nd order	2A SULT	p = 0.0004	0.5562	0.46	8	0.734
	3^rd order**	2A P1 SULT	p < 0.0001	0.6677	<0.005	10	0.372
	4^th order	2A 2C P1 SULT	p < 0.0001	0.6439	<0.021	10	0.372

*1,000-fold permutation test. **Best models selected with maximum cross-validation consistency (CVC) and maximum testing balance accuracy (TBA). Labels: Smk: smoking, Ex3: EPHX1 Tyr113His, Ex4: EPHX1 His139Arg, SULT: SULT1A1 Arg213His, Tbc: tobacco chewing, Alc: alcohol consumption, 2A: CYP1A1*2A, P1: GSTP1 Ile105Val, 2C: CYP1A1*2C.