Table 3.

Differentially methylated regions in the spleen vs. cerebral cortex comparison

Genome Browser Coordinates	Gene Symbol	Distance to Gene	CpG Islands	Higher DNAm	%DNAm Diff.	p-value
Chr4: 80,499,852–80,503,533	Hoxa5	3′ Overlap	2	Spleen	54.0	0.0
Chr12: 45,345,790–45,351,580	Mn1	Inside	1	Spleen	36.2	3.92E-06
Chr15: 14,343,090–14,349,269	Fezf2	1.5 kb 5′	1	Cortex	21.9	7.83E-06
Chr7: 123,673,074–123,677,314	Ppara	52.5 kb 5′	2	Spleen	45.5	1.17E-05
Chr19: 51,894,617–51,898,768	Zcchc14	Inside	1	Spleen	31.6	1.57E-05
Chr10: 87,542,885–87,546,281	Nr1d1	5′ Overlap	1	Spleen	38.8	1.96E-05
Chr7: 118,855,352–118,857,907	Grap2	5′ Overlap	1	Cortex	51.5	2.35E-05
Chr10: 85,047,062–85,050,452	Hoxb4	0.2 kb 5′	2	Spleen	37.9	2.74E-05
Chr15: 33,195,643–33,197,962	Zfhx2	Inside	3	Spleen	50.4	3.13E-05
Chr4: 80,454,745–80,457,885	Hoxa1	5′ Overlap	1	Spleen	38.4	3.52E-05
Chr13: 44,183,144–44,187,850	Rassf5	Inside	2	Spleen	27.2	3.92E-05
Chr7: 27,504,871–27,507,777	Anks1b	5′ Overlap	1	Spleen	52.3	4.31E-05
Chr19: 39,107,355–39,109,768	Pmfbp1	252.7 kb 5′	1	Spleen	56.7	5.09E-05
Chr17: 88,851,952–88,854,869	Cacnb2	5′ Overlap	3	Spleen	53.0	5.48E-05
Chr15: 76,734,160–76,737,397	Pcdh9	5′ Overlap	2	Spleen	42.2	5.87E-05
Chr17: 75,577,618–75,581,390	Klf6	5′ Overlap	3.4 kb	Spleen	33.2	6.26E-05
Chr10: 85,057,553–85,061,796	Hoxb3	Inside	2	Spleen	32.4	7.05E-05
Chr10: 56,586,856–56,588,770	Amac1	4.6 kb 5′	1	Spleen	47.8	8.22E-05
Chr10: 45,223,824–45,226,176	Rnf187	Inside	0.8 kb	Spleen	42.2	8.61E-05
Chr1: 174,113,354–174,117,412	Sox6	43.9 kb 5′	2	Cortex	26.4	9.00E-05

Numbers in the CpG Islands column indicate either the number of CpG islands that overlap the DMR, or if zero, the distance to the closest CpG island. Due to the low number of samples for spleen (N = 4), FDR values were not calculated. Gene names marked in bold indicate genes annotated in the UCSC Genome Browser only for the human and mouse, but presumed to exist in the rat.