Table 1.
Descriptive statistics and characteristics of glioma pedigrees from US used for linkage analyses
| No. of affected individuals in a pedigree | No. of affected individuals in generation(s) | First Stage (n=46) | Second Stage (n=29) | Combined (n=75) |
|---|---|---|---|---|
| 2 | 1 | 14 | 8 | 22 |
| 2 | 13 | 10 | 23 | |
| 3 | 1 | 3 | 4 | |
| 3 | 1 | 7 | -- | 7 |
| 2 | 3 | 5 | 8 | |
| 3 | 2 | 1 | 3 | |
| 4 | 1 | -- | -- | -- |
| 2 | 1 | -- | 1 | |
| 3 | -- | -- | -- | |
| 4 | -- | 1 | 1 | |
| 5 | 1,2 | -- | -- | -- |
| 3 | 3 | -- | 3 | |
| 6 | 1,2 | -- | -- | -- |
| 3 | 2 | 1 | 3 |
| No. of affected male (%) | 61 (48.0) | 41 (58.6) | 102 (51.8) |
| No. of affected female (%) | 66 (52.0) | 29 (41.4) | 95 (48.2) |
| Avg. age (yrs) at dx, proband (SD) | 46.9 (13.4) | 47.6 (14.8) | 45.0 (14.4) |
| Age range at dx, proband | 6–69 | 22–75 | 6–75 |
| Avg. age (yrs) at dx, family (SD) | 46.9 (19.6) | 46.6 (20.5) | 45.3 (19.1) |
| Age range at dx, all affected individuals | 1–86 | 1–85 | 1–86 |
| Total No. Individuals | 1131 | 552 | 1683 |
| Avg. family size | 24.6 | 19.0 | 22.4 |
| No. genotyped (%) | 415 (36.7) | 309 (56.0) | 724 (43.0) |