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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2011 Oct 20;100(3):522–529. doi: 10.1016/j.pbb.2011.10.016

Figure 3.

Figure 3

Rats subjected to intermittent drinking consumed alcohol in bouts which were markedly below the threshold known to produce dependence. Blood ethanol concentrations (BACs, mg/dl) were monitored at (A) 1, (B) 4 and (C) 24 hours of the last 20% alcohol exposure in both the intermittent (N=8) and the continuous access (N=8) groups. (D) Absence of physical signs of withdrawal in the intermittent group (N=10) compared with the continuous one (N=10) measured at 12 hours (T=12h) following the removal of the alcohol bottles (T=0h). The affective component (anxiety) of withdrawal was also absent. Elevated plus maze (EPM)-related variables, including (E) percent (%) open arm time and (F) % open arm entries did not differ between the intermittent and the continuous exposed groups.