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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Crit Care Med. 2012 Jan;40(1):10.1097/CCM.0b013e31822efa14. doi: 10.1097/CCM.0b013e31822efa14

Figure 3. Shock Reversal.

Figure 3

DOC-P improved the mean shock reversal score (calculated from MAP and NE requirements; see Statistical Methods for details) compared to both controls (panel A) and DOC-T-treated animals (panel E) from 32 to 96 h after S. aureus challenge, whereas DOC-T had no significant effect compared to controls on shock reversal during that time period (panel C). DEX-P improved the mean shock reversal score from 32 to 96 h compared to controls (panel B), and there was also an improvement in the shock reversal score with DEX-T that approached significance compared to controls during this time period (panel D). Shock reversal with DEX-P compared to DEX-T was markedly similar from 32 to 96 h, and when combined was significantly improved compared to controls (panel F). (See supplementary Figure 1 for the individual components of shock reversal score over time by treatment group.)