. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Crit Care Med. 2012 Jan;40(1):10.1097/CCM.0b013e31822efa14. doi: 10.1097/CCM.0b013e31822efa14

Table 1. Parameters where treatment effects after S. aureus challenge changed in a different manner with mineralocorticoid vs. glucocorticoid therapy depending on timing of administration (prophylactically vs. therapeutically).

	Desoxycorticosterone (DOC)			Dexamethasone (DEX)				All Controls
Parameter mean ± SEM or 95% CI	Prophylactic (DOC-P)	Therapeutic (DOC-T)	Mean difference	Prophylactic (DEX-P)	Therapeutic (DEX-T)	Mean difference	P-value interaction	Mean value
Survival log hazards ratio	- 0.96 ± 0.55	0.25 ± 0.72	- 1.21	- 0.17 ± 0.54	- 1.17 ± 0.71	+ 1.00	p = 0.05	N/A
Pulmonary function score 12 h to 96 h	0.95 ± 1.35	2.21 ± 1.18	- 1.26	2.21 ± 0.98	1.89 ± 1.10	+ 0.32	p = 0.06	2.08 ± 1.22
Fluid Input (mL/kg/hr) over 96 h	5.7 ± 0.3	6.5 ± 0.7	- 0.8	6.0 ± 0.4	4.8 ± 0.5	+ 1.2	p = 0.05	6.0 ± 0.3
Central venous pressure (mmHg) 4 h to 12 h	5.1 ± 0.4	3.9 ± 0.3	+ 1.2	4.2 ± 0.3	5.4 ± 0.4	- 1.2	p = 0.007	4.6 ± 0.3
Central venous pressure (mmHg) 12 h 30 h	5.6 ± 0.5	4.4 ± 0.6	+ 1.2	4.6 ± 0.6	6.4 ± 0.7	- 1.8	p = 0.005	4.7 ± 0.4
Serum sodium (mEq/L) at 10 h	142.9 ± 1.2	147.3 ± 0.5	- 4.4	145.3 ± 0.8	141.9 ± 0.7	+ 3.4	p = 0.0004	143.0 ± 0.5
Lactate (mmol/L) at 10 h	1.21 ± 0.24	0.72 ± 0.11	+ 0.49	2.74 ± 0.44	1.02 ± 0.10	+ 1.72	p = 0.03	1.00 ± 0.10
Hemoglobin (g/dL) at 10 h	14.7 ± 0.8	16.9 ± 1.6	- 2.2	15.4 ± 0.6	14.3 ± 1.6	+ 1.1	p = 0.06	16.8 ± 0.6
Albumin (g/dL) at 10 h	1.96 ± 0.08	1.98 ± 0.012	- 0.02	2.18 ± 0.05	1.96 ± 0.05	+ .22	p = 0.05	2.04 ± 0.05
Platelets (cells × 10³) at 10 h	245 ± 27	313 ± 31	- 68	248 ± 16	170 ± 30	+ 78	p = 0.02	231 ± 14
Left ventricular ejection fraction (%) at 10 h	0.45 ± 0.04	0.39 ± 0.03	+ 0.06	0.39 ± 0.02	0.49 ± 0.02	- 0.10	p = 0.05	0.41 ± 0.2
IL-6 (pmol/L, log₁₀ scale) at 10 h	3.91 ± 0.08	4.0 ± 0.03	- 0.09	4.21 ± 0.06	3.94 ± 0.13	+ 0.27	p = 0.04	4.06 ± 0.04