Table 3.

Comorbidities in IBS patients vs. controls.

	IBS	Control	IBS vs. Control, Odds Ratio (95%CI)	P-Value	IBS diagnosed by GI*	IBS diagnosed by non-GI*	IBS diagnosed by GI vs. non-GI, Odds Ratio (95%CI)	P-Value
Other Pain Syndromes
Migraine	51,886 (36.7%)	28,380 (20.1%)	2.31 (2.27–2.35)	<0.0001	6,108 (41.7%)	37,534 (36.7%)	1.23 (1.19–1.28)	<0.0001
Fibromyalgia	8,288 (5.9%)	1,900 (1.3%)	4.57 (4.35–4.81)	<0.0001	1,179 (8.1%)	6,070 (5.9%)	1.39 (1.30–1.48)	<0.0001
Chronic Pain	26,467 (18.7%)	10,568 (7.5%)	2.85 (2.78–2.92)	<0.0001	3,781 (25.8%)	19,217 (18.8%)	1.50 (1.44–1.56)	<0.0001
Psychiatric Comorbidities
Anxiety	51,452 (36.4%)	21,724 (15.4%)	3.15 (3.10–3.21)	<0.0001	5,745 (39.2%)	37,773 (37.0%)	1.10 (1.06–1.14)	<0.0001
Depression	55,117 (39.0%)	27,507 (19.5%)	2.65 (2.60–2.69)	<0.0001	6,308 (43.1%)	39,994 (39.1%)	1.18 (1.14–1.22)	<0.0001
Bipolar	4,585 (3.2%)	1,894 (1.3%)	2.47 (2.34–2.61)	<0.0001	594 (4.1%)	3,261 (3.2%)	1.28 (1.17–1.40)	<0.0001
Psychosis	662 (0.5%)	379 (0.3%)	1.75 (1.54–1.99)	<0.0001	106 (0.7%)	463 (0.5%)	1.60 (1.30–1.98)	<0.0001
Other Medical Diagnoses
Diabetes	13,558 (9.6%)	14,730 (10.4%)	0.91 (0.89–0.93)	<0.0001	1,759 (12.0%)	9,643 (9.4%)	1.31 (1.24–1.38)	<0.0001
Celiac Disease	136 (0.1%)	26 (0.0%)	5.23 (3.44–7.96)	<0.0001	28 (0.2%)	100 (0.1%)	1.96 (1.29–2.98)	0.0014
Crohn's Disease	954 (0.7%)	221 (0.2%)	4.34 (3.75–5.02)	<0.0001	313 (2.1%)	499 (0.5%)	4.45 (3.86–5.13)	<0.0001
Colitis	2,723 (1.9%)	774 (0.5%)	3.57 (3.29–3.87)	<0.0001	685 (4.7%)	1,577 (1.5%)	3.13 (2.86–3.43)	<0.0001
Inflammatory Bowel Disease	1,560 (1.1%)	246 (0.2%)	6.40 (5.59– 7.32)	<0.0001	373 (2.5%)	937 (0.9%)	2.83 (2.50–3.19)	<0.0001

IBS: Irritable bowel syndrome; GI: gastroenterologist; SD: Standard deviation; NA: Not applicable

^*Provider specialty known for 83% of IBS patients