Table 4.

Medications prescribed to IBS patients vs. controls.

	IBS	Control	IBS vs. Control, Odds Ratio (95%CI)	P-Value	IBS diagnosed by GI*	IBS diagnosed by non-GI*	IBS diagnosed by GI vs. non-GI, Odds Ratio (95%CI)	P-Value
IBS Prescriptions
Antispasmodics	80,205 (56.8%)	13,112 (9.3%)	12.83 (12.57–13.10)	<0.0001	9,032 (61.7%)	58,106 (56.9%)	1.22 (1.18–1.27)	<0.0001
Prescription Antidiarrheal	21,573 (15.3%)	6,767 (4.8%)	3.58 (3.48–3.69)	<0.0001	3,163 (21.6%)	15,080 (14.8%)	1.59 (1.52–1.66)	<0.0001
Prescription Laxative	4,122 (2.9%)	2,736 (1.9%)	1.52 (1.45–1.60)	<0.0001	698 (4.8%)	2,733 (2.7%)	1.82 (1.67–1.98)	<0.0001
Prescription Fiber	125 (0.1%)	94 (0.1%)	1.33 (1.02–1.74)	0.0361	14 (0.1%)	87 (0.1%)	1.12 (0.64–1.98)	0.6863
Alosetron	133 (0.1%)	2 (0.0%)	66.56 (16.47–268.9)	<0.0001	34 (0.2%)	92 (0.1%)	2.58 (1.74–3.83)	<0.0001
Tegaserod	748 (0.5%)	21 (0.0%)	35.80 (23.20–55.24)	<0.0001	178 (1.2%)	508 (0.5%)	2.46 (2.08–2.92)	<0.0001
Psychiatric cedications
Anxiolytics	62,844 (44.5%)	37,863 (26.8%)	2.19 (2.15–2.22)	<0.0001	7,927 (54.1%)	44,991 (44.0%)	1.50 (1.45–1.55)	<0.0001
Any Antidepressant	77,563 (54.9%)	41,446 (29.3%)	2.93 (2.89–2.98)	<0.0001	9,477 (64.7%)	56,005 (54.8%)	1.51 (1.46–1.57)	<0.0001
Tricyclic Antidepressant	46,656 (33.0%)	19,551 (13.8%)	3.07 (3.01–3.13)	<0.0001	6,473 (44.2%)	33,312 (32.6%)	1.64 (1.58–1.70)	<0.0001
Selective Serotonin Reuptake Inhibitor	50,714 (35.9%)	25,050 (17.7%)	2.60 (2.55–2.64)	<0.0001	6,028 (41.2%)	36,741 (36.0%)	1.25 (1.20–1.29)	<0.0001
Other Antidepressant	37,439 (26.5%)	18,371 (13.0%)	2.41 (2.37–2.46)	<0.0001	4,913 (33.6%)	26,914 (26.3%)	1.41 (1.36–1.47)	<0.0001

IBS: Irritable bowel syndrome; GI: gastroenterologist; SD: Standard deviation; NA: Not applicable

^*Provider specialty known for 83% of IBS patients