Table 4.

Multivariate logistic models for osmolar agent use ≥ 2 days in the first week after injury

		Hypertonic Saline	Mannitol
		aORa (95% CI)	aOR (95% CI)
Age
	0 to 364 days	1.00 (ref.)b	1.00 (ref.)
	1 to <5 years	0.93 (0.74–1.16)	1.26 (1.03–1.54)
	5 to <13 years	1.00 (0.80–1.25)	1.53 (1.28–1.83)
	13 to <18 years	1.40 (1.06–1.87)	1.81 (1.42–2.30)
Insurance status
	Other	1.00 (ref.)	1.00 (ref.)
	Government	1.04 (0.90–1.19)	1.04 (0.86–1.26)
Admission date
	2000-7/2003	1.00 (ref.)	1.00 (ref.)
	8/2003-2008	2.08 (1.43–3.01)	0.69 (0.52–0.91)
Any ICHc
	No	1.00 (ref.)	1.00 (ref.)
	Yes	1.50 (1.13–1.99)	1.62 (1.30–2.01)
Any skull fracture
	No	1.00 (ref.)	1.00 (ref.)
	Yes	1.36 (1.10–1.67)	1.48 (1.18–1.86)
EDHd, no fracture
	No	1.00 (ref.)	1.00 (ref.)
	Yes	0.54 (0.36–0.80)	0.49 (0.28–0.84)
SDHe, no fracture
	No		1.00 (ref.)
	Yes		1.34 (1.03–1.75)
Head/Neck AISf
	3	1.00 (ref.)	1.00 (ref.)
	4	1.26 (0.92–1.73)	1.06 (0.76–1.48)
	5 or 6	1.64 (1.17–2.30)	1.95 (1.47–2.60)
ISSg
	< 15	1.00 (ref.)	1.00 (ref.)
	≥ 15	1.12 (0.84–1.48)	1.01 (0.80–1.28)

^aOdds Ratio, adjusted for clustering by hospital using generalized estimating equations

^bref. = reference category

^cICH = Intracranial hemorrhage

^dEDH = epidural hematoma without skull fracture (ICD-9-CM diagnosis codes 852.4 and 852.5)

^eSDH = subdural hemorrhage without skull fracture (ICD-9-CM diagnosis codes 852.2 and 852.3)

note: “SDH, no fracture” was not significant in the bivariate analysis for hypertonic saline

^fAIS = Abbreviated Injury Scale score, Head/Neck body region, derived using ICDMAP-90

^gISS = Injury Severity Score, derived using ICDMAP-90