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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Aug 16;1823(3):683–688. doi: 10.1016/j.bbamcr.2011.08.006

FIGURE 1. Outline of the Cytosolic Quality Control Process.

FIGURE 1

Three major outcomes for a newly synthesized protein are shown: Folding, aggregation and degradation via the ubiquitin/proteasome system. Proteins shown in blue are co-chaperones that can promote client protein folding. Sse1, shown in purple, promotes degradation of Hsp90 clients. Select ubiquitin ligases known to promote degradation of Hsp90 clients are shown in red. Individual proteins are discussed throughout the review. The process of autophagy, which clears protein aggregates is not depicted.