Table 2.
Central adiposity measurements and thyroid cancer risk in men and women, NIH-AARP Diet and Health Study (1996–2006)
| Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|
| All thyroid cancer | Papillary carcinoma | All thyroid cancer | Papillary carcinoma | |||||
| Cases | HR (95% CI) a | Cases | HR (95% CI) a | Cases | HR (95% CI) a | Cases | HR (95% CI) a | |
| Waist circumference | ||||||||
| Quartile 1b | 17 | 1.00 (Reference) | 13 | 1.00 (Reference) | 29 | 1.00 (Reference) | 21 | 1.00 (Reference) |
| Quartile 2 | 29 | 1.48 (0.81–2.70) | 16 | 1.08 (0.52–2.25) | 15 | 0.57 (0.30–1.06) | 12 | 0.63 (0.31–1.28) |
| Quartile 3 | 25 | 1.71 (0.92–3.17) | 16 | 1.45 (0.69–3.03) | 27 | 0.97 (0.76–2.05) | 19 | 0.96 (0.51–1.79) |
| Quartile 4 | 35 | 2.20 (1.23–3.95) | 29 | 2.43 (1.25–4.70) | 34 | 1.24 (0.76–2.05) | 25 | 1.27 (0.71–2.28) |
| P-trend* | 0.007 | 0.002 | 0.13 | 0.20 | ||||
| Per 5 cm | 106 | 1.10 (1.02–1.20) | 74 | 1.13 (1.03–1.24) | 105 | 1.06 (0.99–1.13) | 77 | 1.07 (0.99–1.16) |
| Normal | 61 | 1.00 (Reference) | 38 | 1.00 (Reference) | 57 | 1.00 (Reference) | 43 | 1.00 (Reference) |
| Large c | 45 | 1.79 (1.21–2.63) | 36 | 2.32 (1.46–3.67) | 48 | 1.54 (1.05–2.26) | 34 | 1.45 (0.92–2.28) |
| Hip circumference | ||||||||
| Quartile 1d | 19 | 1.00 (Reference) | 12 | 1.00 (Reference) | 24 | 1.00 (Reference) | 17 | 1.00 (Reference) |
| Quartile 2 | 22 | 1.23 (0.66–2.28) | 13 | 1.16 (0.53–2.55) | 24 | 1.33 (0.75–2.34) | 16 | 1.22 (0.62–2.42) |
| Quartile 3 | 31 | 1.72 (0.97–3.06) | 23 | 2.04 (1.01–4.12) | 28 | 1.37 (0.80–2.38) | 22 | 1.49 (0.79–2.80) |
| Quartile 4 | 34 | 1.96 (1.11–3.44) | 26 | 2.38 (1.20–4.75) | 29 | 1.41 (0.82–2.43) | 22 | 1.46 (0.77–2.76) |
| P-trend* | 0.01 | 0.004 | 0.24 | 0.22 | ||||
| Per 5 cm | 106 | 1.09 (0.99–1.20) | 74 | 1.11 (1.00–1.24) | 105 | 1.03 (0.95–1.12) | 77 | 1.04 (0.95–1.15) |
| Ratio of waist/hip | ||||||||
| Quartile 1e | 23 | 1.00 (Reference) | 15 | 1.00 (Reference) | 24 | 1.00 (Reference) | 19 | 1.00 (Reference) |
| Quartile 2 | 23 | 0.98 (0.55–1.75) | 18 | 1.19 (0.60–2.37) | 24 | 1.03 (0.58–1.81) | 17 | 0.94 (0.49–1.81) |
| Quartile 3 | 29 | 1.24 (0.72–2.15) | 19 | 1.27 (0.64–2.50) | 26 | 1.09 (0.63–1.91) | 17 | 0.94 (0.49–1.81) |
| Quartile 4 | 31 | 1.36 (0.79–2.33) | 22 | 1.51 (0.78–2.92) | 31 | 1.34 (0.78–2.30) | 24 | 1.39 (0.75–2.54) |
| P-trend* | 0.19 | 0.22 | 0.25 | 0.26 | ||||
| Per 0.1 | 106 | 1.15 (0.91–1.45) | 74 | 1.19 (0.91–1.54) | 105 | 1.21 (0.97–1.50) | 77 | 1.26 (0.98–1.62) |
*
Calculated using the median quartile values modeled as a continuous variable
a
Adjusted for race/ethnicity, education, and smoking status
b
Quartiles for waist circumference: 52.1–91.0, 91.4–96.5, 97.2–104.1, 104.8–173.4 cm in men; 52.1–75.0, 75.6–82.6, 83.2–92.1, 92.7–169.5 cm in women
c
>102 cm for men; >88 cm for women
d
Quartiles for hip circumference: 52.1–97.0, 97.2–101.6, 102.2–108.0, 108.6–175.3 cm in men; 52.1–97.0, 97.2–102.2, 102.9–109.9, 110.5–175.3 cm in women
e
Quartiles for ratio of waist/hip: 0.5092–0.9054, 0.9055–0.9452, 0.9453–0.9865, 0.9866–2.4667 in men; 0.4194–0.7561, 0.7562–0.8047, 0.8048–0.8611, 0.8612–1.8140 in women