Table 4.
Weight change during adulthood and thyroid cancer risk in men and women, NIH-AARP Diet and Health Study (1996–2006)
| Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|
| All thyroid cancer | Papillary carcinoma | All thyroid cancer | Papillary carcinoma | |||||
| Cases | HR (95% CI) | Cases | HR (95% CI) | Cases | HR (95% CI) | Cases | HR (95% CI) | |
| Age 18 to current agea | ||||||||
| Lost ≥5 kg | 2 | 0.73 (0.15–3.56) | 1 | 0.36 (0.04–3.38) | 2 | 0.51 (0.12–2.23) | 2 | 0.70 (0.15–3.18) |
| Lost or gained <5 kg | 10 | 1.00 (Reference) | 8 | 1.00 (Reference) | 23 | 1.00 (Reference) | 17 | 1.00 (Reference) |
| Gained 5–9.9 kg | 14 | 1.40 (0.62–3.16) | 10 | 1.28 (0.50–3.26) | 12 | 0.62 (0.31–1.25) | 6 | 0.42 (0.16–1.06) |
| Gained ≥10 kg | 80 | 1.75 (0.89–3.43) | 55 | 1.57 (0.73–3.35) | 68 | 1.08 (0.67–1.74) | 52 | 1.10 (0.63–1.91) |
| P-trend* | 0.06 | 0.10 | 0.22 | 0.22 | ||||
| Age 18 to 35a | ||||||||
| Lost ≥5 kg | 1 | 0.27 (0.03–2.19) | 1 | 0.34 (0.04–3.01) | 7 | 1.22 (0.53–2.84) | 4 | 0.91 (0.31–2.72) |
| Lost or gained <5 kg | 29 | 1.00 (Reference) | 19 | 1.00 (Reference) | 50 | 1.00 (Reference) | 36 | 1.00 (Reference) |
| Gained 5–9.9 kg | 29 | 1.14 (0.68–1.92) | 23 | 1.41 (0.76–2.60) | 31 | 1.32 (0.84–2.07) | 22 | 1.30 (0.76–2.22) |
| Gained ≥10 kg | 47 | 1.49 (0.93–2.39) | 31 | 1.52 (0.85–2.70) | 17 | 1.28 (0.74–2.24) | 15 | 1.54 (0.84–2.84) |
| P-trend* | 0.03 | 0.08 | 0.50 | 0.16 | ||||
| Age 35 to 50b | ||||||||
| Lost ≥5 kg | 6 | 0.85 (0.35–2.07) | 5 | 0.96 (0.35–2.62) | 3 | 0.63 (0.19–2.10) | 2 | 0.49 (0.11–2.17) |
| Lost or gained <5 kg | 53 | 1.00 (Reference) | 36 | 1.00 (Reference) | 56 | 1.00 (Reference) | 42 | 1.00 (Reference) |
| Gained 5–9.9 kg | 23 | 1.11 (0.68–1.81) | 15 | 1.06 (0.58–1.94) | 26 | 1.15 (0.72–1.84) | 21 | 1.20 (0.71–2.03) |
| Gained ≥10 kg | 24 | 1.49 (0.91–2.43) | 18 | 1.61 (0.90–2.86) | 20 | 1.12 (0.66–1.90) | 12 | 0.83 (0.43–1.59) |
| P-trend* | 0.11 | 0.16 | 0.35 | 0.81 | ||||
| Age 50 to current agec | ||||||||
| Lost ≥5 kg | 11 | 1.16 (0.59–2.29) | 7 | 0.96 (0.41–2.26) | 5 | 0.91 (0.35–2.37) | 3 | 0.76 (0.22–2.58) |
| Lost or gained <5 kg | 64 | 1.00 (Reference) | 46 | 1.00 (Reference) | 65 | 1.00 (Reference) | 47 | 1.00 (Reference) |
| Gained 5–9.9 kg | 16 | 0.96 (0.55–1.67) | 11 | 0.93 (0.48–1.81) | 17 | 0.85 (0.50–1.46) | 14 | 0.99 (0.54–1.81) |
| Gained ≥10 kg | 15 | 1.13 (0.64–1.99) | 10 | 1.05 (0.53–2.11) | 18 | 1.02 (0.60–1.74) | 13 | 1.05 (0.56–1.96) |
| P-trend* | 0.99 | 0.91 | 0.96 | 0.73 | ||||
*
Calculated using the median category values modeled as a continuous variable
a
Adjusted for race/ethnicity, education, smoking status, and weight at age 18
b
Adjusted for race/ethnicity, education, smoking status, and weight at age 35
c
Adjusted for race/ethnicity, education, smoking status, and weight at age 50