Appendix Table.
Associations of BMI and BSA with thyroid cancer risk in men and women, NIH-AARP Diet and Health Study (1996–2006)
| Men | Women | |
|---|---|---|
| HR (95% CI) a | HR (95% CI) a | |
| BMI | ||
| Quartile 1b | 1.00 (Reference) | 1.00 (Reference) |
| Quartile 2 | 1.41 (0.78–2.55) | 0.73 (0.40–1.33) |
| Quartile 3 | 1.37 (0.75–2.50) | 0.98 (0.56–1.71) |
| Quartile 4 | 2.06 (1.18–3.62) | 1.49 (0.89–2.48) |
| P-trend* | 0.01 | 0.04 |
| BSA | ||
| Quartile 1c | 1.00 (Reference) | 1.00 (Reference) |
| Quartile 2 | 1.32 (0.73–2.41) | 1.48 (0.83–2.66) |
| Quartile 3 | 1.55 (0.86–2.79) | 1.55 (0.87–2.77) |
| Quartile 4 | 2.03 (1.15–3.57) | 1.58 (0.88–2.82) |
| P-trend* | 0.01 | 0.16 |
| Mutual adjustment: Model 1 | ||
| BMI | ||
| Quartile 1b | 1.00 (Reference) | 1.00 (Reference) |
| Quartile 2 | 1.27 (0.69–2.35) | 0.77 (0.41–1.43) |
| Quartile 3 | 1.15 (0.59–2.21) | 1.08 (0.56–2.07) |
| Quartile 4 | 1.45 (0.66–3.18) | 1.79 (0.80–4.01) |
| BSA as a continuous variable (per m2) | 2.49 (0.62–10.01) | 0.64 (0.14–2.91) |
| Mutual adjustment: Model 2 | ||
| BMI as a continuous variable (per kg/m2) | 1.04 (0.97–1.11) | 1.02 (0.97–1.09) |
| BSA | ||
| Quartile 1c | 1.00 (Reference) | 1.00 (Reference) |
| Quartile 2 | 1.23 (0.67–2.26) | 1.40 (0.77–2.55) |
| Quartile 3 | 1.35 (0.71–2.55) | 1.38 (0.73–2.62) |
| Quartile 4 | 1.52 (0.71–3.25) | 1.22 (0.52–2.86) |
*
Calculated using the median category values modeled as a continuous variable
a
Adjusted for race/ethnicity, education, and smoking status
b
Quartiles for BMI: 15.1–24.3, 24.4–26.4, 26.4–28.9, 28.9–50.0 kg/m2 in men; 15.0–22.4, 22.4–25.0, 25.0–28.4, 28.4–50.0 kg/m2 in women
c
Quartiles for BSA: 1.41–1.94, 1.94–2.05, 2.05–2.19, 2.19–3.21 m2 in men; 1.19–1.66, 1.66–1.77, 1.77–1.91, 1.91–3.02 m2 in women