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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2011 Oct 4;4(1):79–102. doi: 10.1002/wsbm.162

Figure 1.

Figure 1

Stages of T-cell specification and commitment. Double negative (CD4-CD8-DN) developmental stages before T-cell fate commitment (Phase 1), and immediately after commitment (Phase 2) are shown. Straight arrows represent signal-dependent developmental transitions between successive stages, and the curved arrow represents cytokine-dependent proliferation in the Phase 1 stage. Gray dashed lines represent the commitment checkpoint (left), and two TCR-dependent developmental checkpoints (right). [all figures are original]