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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2011 Oct 4;4(1):79–102. doi: 10.1002/wsbm.162

Figure 5.

Figure 5

Regulatory Gene Circuits Underlying T-Cell Fate Decision Making. A) Coherent feedforward loops for detection of persistent Notch signaling. Shown here are coherent feedforward loops mediating inputs from Notch signaling to Bcl11b (left), as well as to CD25, pTa and Rag1 (right). B) Incoherent feedforward loops and negative feedback loops for detection of IL-7 signal level changes. Shown here is a negative feedback loop regulating expression of IL-7Ra (top), and an incoherent feedforward loop regulating expression of Tcf7 and Lef1 (bottom). C) Positive feedback loops for T-cell fate commitment and exclusion of alternate fates. Shown here are a series of positive feedback loops involving mutual repression between PU.1 and the T-cell regulators TCF-1, Bcl11b, E2A/HEB and Gfi1. Note that TCF-1, Bcl11b, PU.1, HEBAlt and E2A also receive inputs from Notch and/or IL-7 signaling and may hence mediate engagement of the positive feedback loops in response to upstream signals.