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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Cell Physiol. 2012 Apr;227(4):1291–1297. doi: 10.1002/jcp.22815

Fig. 4.

Fig. 4

Systematic mapping of molecular phagocyte biology. Proteins identified by phagocytosis-based functional cloning of ORF phage display can be characterized as membrane-anchored eat-me signals or soluble bridging molecules and used as molecular probes to map their cognate receptors and intracellular signaling cascades by technologies of functional proteomics. This will lead to functional phagoligandomics for systematic mapping of phagocytosis ligands based on their functional activity and functional phagocytomics for systematic mapping of the signaling networks of phagocytes.