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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Sep 22;1825(1):11–17. doi: 10.1016/j.bbcan.2011.09.002

Figure 1. Illustrated pathways of Skp2-mediated degradation of its major downstream targets.

Figure 1

The SCF (Skp1-Cullin 1-F-box) complex consists of four components: the invariable component Skp1 (adaptor protein), Rbx1 (RING finger protein) and Cullin1 (Scaffold protein), and the interchangeable F-box protein that functions as a receptor for target proteins. Skp2 recognizes the targeted substrates, which are presented closely to the E2 enzyme to ensure consequent conjugation of ubiquitin. The addition of polyubiquitin targets proteins to the 26S-proteasome for degradation. The specific substrates of Skp2 include p21, p27, p57, p103, Tob1, FOXO1, and c-Myc.