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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Sep 22;1825(1):11–17. doi: 10.1016/j.bbcan.2011.09.002

Figure 2. Diagram of Skp2 cross-talks with other pathways in prostate cancer.

Figure 2

PI3K/Akt, PTEN and AR regulate the expression of Skp2 in prostate cancer. Skp2 regulates the abundance of its substrates p27, p21 as well as the expression of ATF4 and BRCA2. Skp2 inhibitors including natural agents such as silibinin could induce cell cycle arrest through downregulation of Skp2 expression in prostate cancer. Skp2: S-phase kinase associated protein 2; AR: androgen receptor; BRCA2: breast cancer 2; PI3K: phosphatidylinositol 3-kinase; PTEN: phosphatase and tensin homolog on chromosome 10.