Figure 3.
Effects of MyD88 deficiency on APP or WT mice on Morris water maze. Total cumulated scores per day for path length (cm) (A) and escape latencies (s) (B). Means ± SEM are shown during acquisition of the hidden platform task. MyD88 deficiency improved performance of APP and WT mice. (C) The probe trial of the Morris water maze. Percent of time spent in the target quadrant in which the hidden platform was previously placed. The dashed line indicates the chance level (25%). All groups spent significantly longer than chance in the target quadrant (P < 0.05) and no difference was found in any group. * P < 0.05: MyD88 deficient groups vs. MyD88 sufficient groups, ** P < 0.01: APP groups vs. non-APP groups.