Table 1.
Effects of MyD88 deficiency on exploratory activity (means ± SEM)
| Test | APP MyD88 -/- | APP | MyD88 -/- | WT |
|---|---|---|---|---|
| T-maze | ||||
| Alternations (%) | 61 ± 5 | 56 ± 4 | 60 ± 3 | 59 ± 3 |
| Choice latencies/trial (s) | 15.9 ± 4 | 11.4 ± 2 | 20 ± 7 | 14.5 ± 5 |
| Elevated Plus-Maze | ||||
| Day 1 | ||||
| Open Arms | ||||
| Entries | 8. 9 ± 1.4 | 10.4 ± 1.1 | 8.6 ± 1.5 | 12.3 ± 1.0 |
| Duration (s) | 68.0 ± 17.3 | 69.8 ± 19.8 | 62.6 ± 14.9 | 100.9 ± 17.8 |
| Enclosed Arms | ||||
| Entries | 10.2 ± 1.2 | 10.1 ± 1.7 | 12.5 ± 1.1 | 9.6 ± 1.6 |
| Duration (s) | 199.4 ± 15.7 | 201.1 ± 20.8 | 202.0 ± 17.0 | 168.7 ± 18.5 |
| Open/total Ratio % | ||||
| Entries | 45.2 ± 5.1a | 50.2 ± 6.2 | 39.0 ± 3.3a | 56.0 ± 2.8 |
| Duration (s) | 22.7 ± 5.8 | 23.3 ± 6.6 | 20.9 ± 5.0 | 33.7 ± 5.9 |
| Day 2 | ||||
| Open Arms | ||||
| Entries | 2.4 ± 0.6 | 5.4 ± 2.2 | 3.1 ± 0.8 | 5.4 ± 2.0 |
| Duration (s) | 9.9 ± 3.4 | 31.1 ± 12.4 | 12.1 ± 3.6 | 26.5 ± 11.0 |
| Enclosed Arms | ||||
| Entries | 8.6 ± 1.4 | 7.8 ± 1.6 | 7.9 ± 1.6 | 8.9 ± 1.6 |
| Duration (s) | 271.5 ± 6.3 | 251.7 ± 14.8 | 268.4 ± 6.1 | 251.1 ± 12.9 |
| Open/total Ratio % | ||||
| Entries | 20.6 ± 5.2 | 32.6 ± 7.0 | 27.1 ± 6.9 | 29.2 ± 6.3 |
| Duration (s) | 3.3 ± 1.1 | 10.4 ± 4.1 | 4.0 ± 1.2 | 8.8 ± 3.7 |
a
P < 0.05 for either MyD88 or APP effects on ANOVA