Table 2.
Effects of MyD88 deficiency on APP or WT mice on stationary beam and coat-hanger tests (means ± SEM)
| Measures | APP MyD88 -/- | APP | MyD88 -/- | WT |
|---|---|---|---|---|
| Stationary Beam | ||||
| Segments | 15 ± 5a | 20 ± 9a | 46 ± 11 | 68 ± 12 |
| Latencies before falling (s) | 220 ± 7a | 168 ± 16 | 223 ± 12a | 203 ± 14 |
| Falls | 0.8 ± 0.3a | 2.1 ± 0.5 | 0.4 ± 0.3a | 1.0 ± 0.4 |
| Coat-Hanger | ||||
| MT-1 (s) | 150 ± 21a | 111 ± 11 | 150 ± 20a | 99 ± 24 |
| MT-2 (s) | 200 ± 14a | 154 ± 14 | 195 ± 8a | 147 ± 24 |
| Two-paw MT (s) | 239 ± 1 | 239 ± 2 | 225 ± 6 | 223 ± 9 |
| Three-paw MT (s) | 239 ± 0.3 | 239 ± 1 | 232 ± 5 | 240 ± 0 |
| Four-paw MT (s) | 240 ± 0 | 239 ± 1 | 233 ± 5 | 240 ± 0 |
| Midway MT (s) | 240 ± 0 | 240 ± 0 | 240 ± 0 | 240 ± 0 |
| Top MT (s) | 240 ± 0 | 240 ± 0 | 240 ± 0 | 240 ± 0 |
| Fall Latencies (s) | 212 ± 9a | 174 ± 15 | 187 ± 17a | 141 ± 21 |
| Falls | 1.3 ± 0.3a | 2.7 ± 0.4 | 1.9 ± 0.5a | 2.8 ± 0.4 |
a
Any of these groups are significantly different from any of the other groups in the indicated measures (P < 0.05 for either MyD88 or APP effects on ANOVA).