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. Author manuscript; available in PMC: 2011 Dec 20.
Published in final edited form as: Microbes Infect. 2007 Jan 27;9(5):615–622. doi: 10.1016/j.micinf.2007.01.012

Fig. 6.

Fig. 6

Fungal burdens are significantly reduced after mucosal immunization with a putative C. albicans virulence factor. Balb/c mice (n = 10) induced into a state of pseudoestrus (see Section 2) were immunized intranasally with 5 μg of C. albicans secreted aspartyl protease (Sap2) and 1 μg cholera toxin or PBS (control). Two weeks after immunization, mice were challenged orally and vaginally with C. albicans 529L as described. Weekly oral swabs and vaginal washings were collected and fungal burdens followed for an additional 5 weeks (mean ± S.E.M.). Significant reduction in fungal burdens was observed orally at week 2 (*P < 0.05) and at week 7 both orally (**P < 0.001) and vaginally (**P < 0.0001). The data are representative of two independent experiments.