Table 3.

Population pharmacokinetic parameters of ceftriaxone

	Estimation				Bootstrap
Parameter	Final estimate	SE of the estimate	95% CI*		Median	95% CI†
PK
CL (l h−1) = θ1+θ2× (CLcr/4.26)
θ1	0.56	0.11	0.34	0.78	0.56	0.37	0.85
θ2	0.32	0.12	0.08	0.56	0.32	0.005	0.56
V1 (l)	10.3	0.89	8.56	12.04	10.0	6.24	13.4
V2 (l)	7.35	0.75	5.88	8.82	7.48	4.81	10.9
Q (l h−1)	5.28	1.37	2.59	7.97	5.12	1.16	14.4
BSV ω2 (% coefficient variation)
ω2 (CL)	0.24 (49)	0.05	0.14	0.34	0.25	0.15	0.38
ω2 (V1)	0.23 (48)	0.06	0.11	0.35	0.24	0.11	0.43
ω2 (V2)	0.42 (65)	0.11	0.20	0.64	0.38	0.18	1.76
Residual variability σ2
σ2 proportional (%)	24	0.009	21	28	24	21	28

^*(mean estimate ± 1.96 SE of the estimates) for θ; (mean estimate ± 1.96 SE of the estimates)^1/2 for ω and σ.

^†The 2.5^th and 97.5^th percentiles of 500 bootstrap distribution of parameter estimates. V1, volume of the central compartment; V2, volume of the peripheral compartment; CL, clearance of ceftriaxone; CL_cr, clearance of creatinine; Q, intercompartmental clearance.