Figure 4.

Restricted activation of canonical Wnt/β-catenin pathway during lens development. Mouse TCF/lef reporter gene assay shows transient strong Wnt/β-catenin pathway activity in most anterior lens epithelial cells around E13.5 (A). Reporter activity is absent from lens fibers at E13.5 (A) and P3 (B). In contrast, the reporter gene activity first detected in the peripheral region of the optic cup (A) extends through embryonic development and remains prominent in this region postnatally, particularly where the ciliary body differentiates (B).