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A representative synthetic scheme for G5 PAMAM dendrimers presenting either folic acid (FA) or methotrexate (MTX) molecule in multiple copies. (i) Ac2O, MeOH, rt; (ii) folic acid, EDC, DMSO, DMF, rt, 24 h; (iii) Ac2O, DMSO, rt; (iv) variable amounts of methotrexate, EDC, DMF, DMSO, rt, 24 h.
