Table 1.
Microarray analysis of selected genes of interest from a total of 357 genes that are at least twofold up- or down-regulated (p < 0.05; n = 3) across age namely E10, E14, E17, and E20 when subjected to normoxic treatment.
| Category | p-Value | E10N/E10N | E14N/E10N | E17N/E10N | E20N/E10N | Description |
|---|---|---|---|---|---|---|
| Growth Factors | 0.010 | 1.00 | 0.90 | 2.03 | 3.16 | Eph receptor A5. [Source: Uniprot/SPTREMBL; Acc: Q8C276] |
| 0.024 | 1.00 | 1.52 | 2.01 | 1.54 | Endothelin B receptor precursor (ET-B) [Source: Uniprot/SWISSPROT; Acc: P48302] | |
| 0.040 | 1.00 | 2.32 | 2.26 | 2.02 | Platelet-derived growth factor, C polypeptide; fallotein. [Source: RefSeq; Acc: NM 019971] | |
| 0.010 | 1.00 | 2.83 | 3.73 | 3.83 | Transforming growth factor, beta induced, 68 kDa. [Source: RefSeq; Acc: NM 009369] | |
| Contractile Proteins | 0.010 | 1.00 | 3.41 | 12.61 | 7.41 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2; MLC-2v). [Source: Uniprot/SWISSPROT; Acc: P51667] |
| 0.024 | 1.00 | 0.82 | 0.84 | 1.89 | Actin, alpha skeletal muscle (Alpha-actin 1). [Source: Uniprot/SWISSPROTAcc: P02568] | |
| 0.031 | 1.00 | 2.12 | 3.07 | 3.94 | Troponin I, cardiac (Tnni3) | |
| 0.044 | 1.00 | 2.41 | 3.83 | 5.06 | Troponin T, cardiac muscle isoforms (cTnT). [Source: Uniprot/SWISSPROTAcc: P50752] | |
| 0.044 | 1.00 | 0.75 | 1.49 | 1.64 | Troponin T, fast skeletal muscle isoforms. [Source: Uniprot/SWISSPROTAcc: Q9QZ47] | |
| 0.014 | 1.00 | 0.83 | 1.44 | 2.77 | Cardiac phospholamban (PLB). [Source: Uniprot/SWISSPROT; Acc: P61014] | |
| Transcription Factors | 0.034 | 1.00 | 0.53 | 1.24 | 2.29 | Transcription factor SOX-10 (SOX-21; Transcription factor SOX-M). [Source: Uniprot/SWISSPROT; Acc: Q04888] |
| Other Proteins | 0.031 | 1.00 | 4.86 | 7.55 | 6.12 | Procollagen, type III, alpha 1 (Col3al) |
| 0.008 | 1.00 | 0.48 | 0.90 | 0.93 | Procollagen, type XV. [Source: RefSeq; Acc: NM 009928] | |
| 0.035 | 1.00 | 1.63 | 1.24 | 2.18 | Natriuretic peptides B precursor [Gamma-brain natriuretic peptide; Brain natriuretic peptide (BNP)]. [Source: Uniprot/SWISSPROT; Acc: P40753] | |
| 0.049 | 1.00 | 0.87 | 2.03 | 2.29 | Coagulation factor VIII precursor (Procoagulant component). [Source: Uniprot/SWISSPROT; Acc: Q06194] | |
| 0.010 | 1.00 | 2.30 | 5.98 | 6.10 | Vitronectin precursor (Serum spreading factor; S-protein). [Source: Uniprot/SWISSPROT; Acc: P29788] | |
| 0.012 | 1.00 | 0.97 | 1.55 | 2.52 | Protocadherin alpha 12; cadherin-related neuronal receptor 5; protocadherin alpha 13. [Source: RefSeq; Acc: NM 138663] |
Fold changes across all time points are normalized to E10N.