Table 2.

Microarray analysis of selected genes of interest from a total of 995 genes that are at least twofold up- or down-regulated (p < 0.05; n = 3) across age namely E10–E20 when subjected to hypoxic treatment.

Category	p-Value	E10H/E10H	E14H/E10H	E17H/E10H	E20H/E10H	Description
Hypoxia induced	0.003	1	2.22	2.26	2.40	EROl-like. [Source: RefSeq; Acc: NM_015774]
Growth factors	0.028	1	0.85	0.87	0.45	Vascular endothelial growth factor receptor 1 precursor (VEGFR 1; Tyrosine-protein kinase receptor FLT; FLT-1) [Source: Uniprot/SWISSPROT; Acc: P35969]
	0.045	1	1.59	0.93	2.08	Vascular endothelial growth factor A precursor (VEGF-A; Vascular permeability factor, VPF). [Source: Uniprot/SWISSPROT; Acc: Q00731]
	0.032	1	1.94	2.04	0.97	Ephrin type-A receptor 7 precursor (Tyrosine-protein kinase receptor EHK-3) [Source: Uniprot/SWISSPROT; Acc: 061772]
	0.047	1	0.70	0.43	0.59	Transforming growth factor beta 4 precursor (TGF-beta 4; Left protein) [Source: Uniprot/SWISSPROT; Acc: O64280]
	0.036	1	1.74	2.06	2.11	Insulin-like growth factor II precursor (IGF-II). [Source: Uniprot/SWISSPROT; Acc: P09535]
Contractile proteins	0.035	1	2.35	1.50	1.15	Myosin X (Myo 10)
	0.021	1	3.01	4.43	5.84	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha). [Source: Uniprot/SWISSPROT; Acc: Q02566]
	0.001	1	1.05	1.14	2.34	Actin, aortic smooth muscle (Alpha-actin 2). [Source: Uniprot/SWISSPROT; Acc: P03996]
	0.035	1	3.00	4.86	6.72	Actin. alpha cardiac. [Source: Uniprot/SWISSPROT: Acc: P04270]
	0.011	1	1.05	2.97	2.52	Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform). [Source: Uniprot/SWISSPROT; Acc: Q9WUZ5]
Transcription factors	0.034	1	1.71	1.17	0.78	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Source: Uniprot/SWISSPROT; Acc: P31695]
Cytokines/chemokines	0.034	1	1.28	2.12	1.70	Interleukin-4 induced protein 1 precursor (FIG-1 protein; mFIG1). [Source: Uniprot/SWISSPROT: Acc: O09046]
	0.035	1	0.42	0.44	0.60	Interleukin-6 precursor (IL-6; Interleukin HP-1; B-cell hybridoma growth factor). [Source: Uniprot/SWISSPROT; Acc: P08505]
Other proteins	0.011	1	0.75	1.19	2.44	CYR61 protein precursor (Cysteine-rich, angiogenic inducer, 61 (Insulin-like growth factor-binding protein 10; 3CH61). [Source: Uniprot/SWISSPROT; Acc: P18406]
	0.033	1	0.74	0.86	1.50	Myocyte-specific enhancer factor 2A. [Source: Uniprot/SWISSPROT; Acc: Q60929]
	0.029	1	0.95	0.67	0.47	Myocardin (SRF cofactor protein; Basic SAP coiled-coil transcription activator 2). [Source: Uniprot/SWISSPROT; Acc: Q8VIM5]
	0.036	1	2.73	2.74	1.74	Semaphorin 6A precursor (Semaphorin VIA; SEMA6A-1; Semaphorin Q; Sema Q). [Source: Uniprot/SWISSPROT; Acc: 035464]

Fold changes across all time points are normalized to E10H.