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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Expert Rev Vaccines. 2011 Nov;10(11):1553–1568. doi: 10.1586/erv.11.124

Figure 1. Functional domains in heat shock protein A and heat shock protein C family members.

Figure 1

Heat shock protein (HSP)A (Hsp70, large HSP) and HSPC (Hsp90, GP96) each possess two major domains including a nucleotide (ATP, ADP) binding domain and a polypeptide (substrate) binding domain. When ATP binds to the HSP, the polypeptide-binding domain opens and cargo dissociates. When ADP binds to the nucleotide-binding domain, polypeptide cargo is bound and in this form HSP may capture and chaperone tumor antigens. These two domains, although similar in function, may differ considerably between individual HSPs. Pi: Phosphate; S: Substrate.