Table 2.
KEGG terms that are significantly enriched in the 142 schizophrenia related drug target genes. The P-values were estimated by the hypergeometric test and then adjusted by Bonferroni multiple testing correction (Adj. P-values).
| KEGG ID | KEGG Pathway Description | # Genes (%) | P-value | Adj. P-value |
|---|---|---|---|---|
| hsa04080 | Neuroactive Ligand-receptor Interaction | 52 (36.62) | 7.36 × 10−82 | 1.03 × 10−80 |
| hsa01100 | Metabolic Pathways | 42 (29.58) | 3.02 × 10−34 | 4.23 × 10−33 |
| hsa00250 | Alanine, Aspartate and Glutamate Metabolism | 15 (10.56) | 2.09 × 10−30 | 2.93 × 10−29 |
| hsa04020 | Calcium Signaling Pathway | 21 (14.79) | 1.72 × 10−27 | 2.41 × 10−26 |
| hsa00260 | Glycine, Serine and Threonine Metabolism | 12 (8.45) | 4.75 × 10−23 | 6.65 × 10−22 |
| hsa00330 | Arginine and Proline Metabolism | 10 (7.04) | 9.71 × 10−16 | 1.36 × 10−14 |
| hsa05014 | Amyotrophic Lateral Sclerosis (ALS) | 8 (5.63) | 4.47 × 10−12 | 6.26 × 10−11 |
| hsa04720 | Long-term Potentiation | 8 (5.63) | 4.56 × 10−11 | 6.38 × 10−10 |