Table 1.

bPΔ6-hPAP treatment leads to fewer tumor nodules in a metastatic tumor model. TRAMP-C2 cells (5×10⁵/mouse) were injected intravenously in the tail vain of C57/BL6 mice (N=8/group) and lung tumors established as previously described ²⁸. Preliminary studies showed microscopic tumor nodules by day 25 and by day 60 animals showed signs of morbidity. Mice were treated 4 times with 3×10⁷ pfu of bPΔ6-hPAP, bPΔ6-mPAP or bPΔ6-empty, or PBS over a period of 10 days. Animals were sacrificed at day 60 and the number of lung tumor nodules and tumor burden per mouse was analyzed as described previously ²⁸. Animals treated with bPΔ6-hPAP viruses showed significantly fewer tumor nodules when compared with bPΔ6-mPAP or PBS groups (* p=0.02), as well as a decrease in tumor burden (** p=0.03 vs bPΔ6-empty). There was no statistical difference between tumor nodules in the bPΔ6-Empty versus PBS groups. Pairwise statistical analysis were performed using Student’s T-Tests.

	PBS	empty	mPAP	hPAP
Total tumor nodules	8	18	10	4*
Mean tumor burden per mouse (cm2)	7.0	16.8	6.9	1.6**