Figure 2.

Domains of the ABI3/VP1 proteins.ABI3 and VP1 contain 4 conserved domains, designated as A, B1, B2 and B3. The N-terminal domain A is rich in acidic residues. One of the basic domains, B1, is necessary for physical interaction with bZIP transcription factors such as ABI5. The B2 domain contains a putative nuclear localization signal and is also suggested to function in other transcriptional regulation. The B3 domain is the DNA-binding domain that is highly conserved. The structure of FUS3 is a truncated version of ABI3/VP1. This contains only the B3 domain and an incomplete B2 domain.