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Effects of c-Myc on the cyotoxicity of CDDP. (a) Ela-mycPT1 cells and D1.5 cells transfected with a c-myc cDNA construct show higher levels of c-myc mRNA detected by RT-PCR assay, compared with the corresponding pcDNA3.1-hygro vector transfectants. HPRT1 is included as a loading control. (b and c) c-myc transfected Ela-mycPT1 cells (b) and D1.5 cells (c) show a less cell viability during 12-60 hours of CDDP treatment, compared with the corresponding vector transfected cells
