Table 1.
CML Response Criteria Definition (from30)
| Hematologic | Cytogenetic | Molecular |
|---|---|---|
| Complete: Normal complete blood cell count, non-palpable spleen and disappearance of all disease signs and symptoms | Complete: 0% Ph+-metaphases | Complete: Undetectable BCR-ABL1 transcripts on two consecutive quantitative RT-PCR or nested PCR assays (sensitivity at least 10−4) |
| Partial: 1–35% Ph+-metaphases | Major: Ratio BCR-ABL1:ABL1 transcripts ≤ 0.1% in the international scale by quantitative RT-PCR | |
| Major: 0–35% Ph+-metaphases | ||
| Minor: 36–65% Ph+-metaphases | ||
| Minimal: 66–95% Ph+-Metaphases | ||
| No Response: ≥ 96% Ph+-metaphases |