Table 5.

Studies with Nilotinib as Salvage Therapy for Imatinib Resistance or Intolerance

Study	Disease Stage	N	% Response
			Hematologic Response		Cytogenetic Response
			HR	CHR	MCyR	CCyR
Phase I70	CP	17	92	92	35	35
	AP	56	74	51	27	14
	BP	33	39	6	18	6
	Ph+-ALL	10	10	-	-	-
Phase II	CP72	321	NR	76	59	44
	AP73	134	56	30	32	19
	BP71	135	38	25	-	-
	Ph+-ALL74	41	27	24	-	-

Abbreviations: AP, advanced phase; BP, blast phase; CCyR, Complete Cytogenetic Response; CHR, Complete Hematological Response; CP, Chronic Phase; HR, Hematological Response; MCyR, Major Cytogenetic Response Ph+-ALL, Philadelphia-Positive Acute Lymphoblastic Leukemia;