Table 1.
Current clinically approved and upcoming nerve guidance conduits.
| product | company | composition | degradation time | max length |
|---|---|---|---|---|
| Neurogen | Integra Neurosciences, Plainsboru, NJ, USA | collagen type I | 4 years | 3 cm |
| NeuraWrap | Integra Neurosciences, Plainsboru, NJ, USA | collagen type I | 4 years | 4 cm |
| Neuromend | Collagen Matrix, Inc., Franklin Lakes, NJ, USA | collagen type I | 4–8 months | 2.5 cm |
| Neuromatrix/Neuroflex | Collagen Matrix, Inc., Franklin Lakes, NJ, USA | collagen type I | 4–8 months | 2.5 cm |
| Neurotube | Synovis Micro Companies Alliance, Birmingham, AL, USA | woven polyglycolic acid (PGA) | 6–12 months | 3 cm |
| Neurolac | Polyganics Inc., The Netherlands | poly(dl-lactic-co-ɛ-caprolactone) (PLCL) | 2–3 years | 3 cm |
| Salubridge/Hydrosheath or Salutunnel | Salumedica LLC, Atlanta, GA, USA | Salubria—polyvinyl alcohol (PVA) hydrogel | non-biodegradable | 6.35 cm |
| Surgisis Nerve Cuff/Axoguard | Cook Biotech Products, West Lafayette, IN, USA | porcine small intestinal submucosa (SIS) matrix | not reported | 4 cm |
| AxonScaff/Cellscaff/ StemScaff (filing for CE and FDA approval) | Axongen, Umeå, Sweden | polyhydroxybuturate (PHB) | not reported | not reported |