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Cartoon representations of two-component phosphotransfer schemes.(A) A basic prokaryotic two-component system with a sensor histidine kinase and a response regulator. H and D represent the conserved phospho-accepting histidine and aspartate residues involved in phosphorelay signaling. (B) A multistep phosphorelay system involving a hybrid sensor kinase, with input, transmitter and receiver domains, a histidine-containing phosphotransfer protein and a response regulator.
