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. 2012 Jan;53(1):137–148. doi: 10.1194/jlr.M020065

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Fig. 6. — CCK-stimulated intracellular calcium responses at chimeric CCK2R/CCK1R receptors. Shown are the CCK concentration-dependent calcium response curves in chimeric receptor constructs after depletion of membrane cholesterol with MβCD and enrichment of membrane cholesterol with MβCD-cholesterol treatment. Both CCK2R(ex1)1R(ex2-5) and CCK2R(ex1-2)1R(ex3-5) constructs exhibited rightward shifts suggesting lower potency of calcium responses, whereas CCK2R(ex1-3)1R(ex4-5) and CCK2R(ex1-4)1R(ex5) exhibited no change in calcium responses. Intracellular calcium responses are expressed as percentages of maximal responses for each condition. Data represent means ± SEM of three to nine independent experiments performed in triplicate.