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. Author manuscript; available in PMC: 2011 Dec 20.
Published in final edited form as: Proteomics Clin Appl. 2010 Jan 4;4(3):295–303. doi: 10.1002/prca.200900083

FIGURE 1. AUTOMATED BRAIN SEGMENTATION.

FIGURE 1

BRAIN ATROPHY CAN BE SEEN ON CONVENTIONAL MR IMAGES OF HIV INFECTED PATIENTS. IT IS DIFFICULT TO DETERMINE OF INJURY BASED ON VISUAL INSPECTION. AUTOMATED IMAGE PROCESSING ALGORITHMS CAN BE USED TO QUANTIFY THE BRAIN PARENCHYMA FRACTION, RELATIVE TO NORMATIVE POPULATION VALUES. VOLUME FRACTIONS OF GRAY MATTER, WHITE MATTER AND CSF CAN BE DETERMINED FOR EACH SUBJECT RELATIVE TO THE INDIVIDUAL INTRACRANIAL CAVITY (ICC) VOLUME (RIGHT). THESE ALGORITHMS REQUIRE MINIMAL OPERATOR, THEREBY MINIMIZING INTER- AND INTRA-RATER VARIATION IN BRAIN VOLUMETRIC MEASUREMENT.