FIGURE 6.
Gabazine blocked muscle GABAA receptors. A, a representative experiment showing the effect of gabazine (0.5 mm) on spontaneous postsynaptic currents (“minis”) mediated by GABAA receptors (upward events). B, a representative experiment showing the effect of gabazine (0.5 mm) on photo-evoked IPSCs in a worm expressing channelrhodopsin-2 in GABAergic neurons. The traces from top to bottom are light pulses, postsynaptic currents including IPSCs at a longer time scale, and the IPSCs at a shorter time scale. C, comparisons of the effects of gabazine on the frequency of “minis” and amplitude of IPSCs. The asterisk indicates a significant difference (p < 0.01, paired t test) compared with the control (before gabazine treatment). The data are shown as the means ± S.E. Minis and IPSCs were recorded from six and eight muscle cells, respectively.