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Size-exclusion chromatography experiments of wild-type DISC1 and DISC1-S704C suggest DISC1-S704C forms a higher molecular weight oligomeric species compared with wild-type. a, SDS-PAGE gel shows homogenous purification of MBP-DISC1 and S704C variant. b, size-exclusion chromatography of wild-type DISC1 (continuous line) and DISC1S704C variant (dashed line).
