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. 2011 Oct 27;286(51):43871–43880. doi: 10.1074/jbc.M111.297515

FIGURE 6.

FIGURE 6.

D-JNKI1′ effect on APP processing. A, p-APP/APP ratio. Representative Western blot and relative quantification showed that the p-APP/total APP ratio is reduced in the cortex and hippocampus of Tg DJNKI1 mice compared with controls. Data are expressed as mean ± S.E. *, p < 0.05 (Tg vehicle (n = 8) versus Tg D-JNKI1 (n = 8); Student's t test). B, APP fragments Western blots and relative quantifications. The C-99/C-83 ratio was reduced by 70% in the cortex and 40% in the hippocampus of Tg D-JNKI1 mice compared with controls. Data are expressed as mean ± S.E. **, p < 0.01; ***, p < 0.001 (Tg vehicle (n = 8) versus Tg D-JNKI1 (n = 8); Student's t test). C, soluble αAPP and βAPP Western blots and relative quantifications. βAPP/αAPP ratio was reduced by 70% in the cortex and 45% in the hippocampus of Tg DJNKI1 mice. Data are expressed as mean ± S.E. *, p < 0.05; **, p < 0.01 (Tg vehicle (n = 8) versus Tg D-JNKI1 (n = 8); Student's t test). D, Western blots and relative quantifications. Formation of toxic soluble Aβ trimers is reduced by 78% and of dodecamers by 70% in the cortex of Tg D-JNKI1-treated mice. Formation of toxic soluble Aβ trimers is reduced by 60% and of dodecamers by 60% in the hippocampus of Tg D-JNKI1 treated mice. Data are expressed as mean ± S.E. **, p < 0.01; ***, p < 0.001 (Tg vehicle (veh; n = 8) versus Tg D-JNKI1 (n = 8); Student's t test).