TABLE 1.
Analysis of major toxicological markers in plasma demonstrates that D-JNKI1 chronic treatment does not lead to any major side effects in mice
Data are expressed as mean (S.E.) (two-way ANOVA); NS, not significant.
| WT vehicle | WT D-JNKI | Tg vehicle | Tg D-JNKI1 | Two-way ANOVA | |
|---|---|---|---|---|---|
| Number | 6 | 4 | 6 | 4 | |
| Bilirubin total (μmol/liter) | 0.110 (0.031) | 0.143 (0.091) | 0.128 (0.026) | 0.065 (0.019) | NS |
| Calcium (μmol/liter) | 2.192 (0.109) | 2.468 (0.107) | 2.354 (0.079) | 2.430 (0.099) | NS |
| Creatinine (μmol/liter) | 0.268 (0.011) | 0.285 (0.009) | 0.272 (0.005) | 0.285 (0.017) | NS |
| Glutamyloxaloacetic transaminase (units/liter) | 187.3 (96.600) | 194.4 (74.114) | 111.8 (21.086) | 130.6 (32.363) | NS |
| Glutamylpyruvic transaminase (units/liter) | 88.6 (53.272) | 58.4 (16.703) | 28.9 (7.101) | 35.6 (7.454) | NS |
| Urea (mmol/liter) | 34.2 (2.873) | 45.8 (2.406) | 51.2 (2.160) | 60.1 (6.360) | NS |
| α-Amylase (units/liter) | 2673.3 (141.270) | 3134.7 (200.073) | 2704.5 (170.604) | 2744.8 (297.337) | NS |
| Alkaline phosphatase (units/liter) | 106.4 (15.836) | 75.5 (9.805) | 85.2 (12.065) | 85.0 (7.524) | NS |
| Lactate dehydrogenase (units/liter) | 442.5 (165.561) | 395.8 (71.976) | 264.9 (34.254) | 379.0 (60.603) | NS |
| Sodium (mmol/liter) | 162.4 (2.401) | 156.9 (1.165) | 160.0 (2.988) | 164.3 (1.971) | NS |
| Potassium (mmol/liter) | 6.578 (0.218) | 7.107 (0.462) | 7.314 (0.460) | 6.90 (0.398) | NS |
| Chlorine (mmol/liter) | 112.3 (1.192) | 111.6 (4.148) | 111.2 (1.623) | 115.1 (0.971) | NS |