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Type II collagen was reduced with Erk signal suppression in Col2-RB1CC1 (RB1CC1/Cre) mice. FLAG (exogenous RB1CC1; arrows) was seen only in the chondrocytic cytoplasm of day 18.5 RB1CC1/Cre embryos, and type II collagen in the chondroid matrix and phosphorylated Erk (202/204; arrowheads) in the chondrocytic nuclei were prominently reduced. Scale bar, 100 μm.
