TABLE 2.
Decreased transcription of hBMEC genes after infection with Δstp1
Gene expression is denoted as -fold difference relative to the WT GBS strain A909. Only genes that showed a >2-fold change (p < 0.05) in expression compared with WT A909 are listed.
| Δstp1 | |
|---|---|
| Chemokines and cytokines | |
| Chemokine (C-C motif) ligand 20 (CCL20) | 0.246 |
| Interleukin-6 (IL-6) | 0.237 |
| Tumor necrosis factor (TNFα) | 0.191 |
| Interleukin-8 (IL-8) | 0.167 |
| Cardiotrophin-like cytokine factor 1 (CLCF1) | 0.038 |
| Colony-stimulating factor 2 (granulocyte-macrophage) (CSF2) | 0.030 |
| Transcriptional factors/signal transduction | |
| Baculoviral IAP repeat (BIRC3) | 0.278 |
| Serpin peptidase inhibitor, clade E (SERPINE1) | 0.156 |
| Dual specificity phosphatase 5 (DUSP5) | 0.123 |
| Leukemia inhibitory factor (cholinergic differentiation factor) (LIF) | 0.117 |
| Sprouty homolog 4 (SPRY4) | 0.109 |
| Protein phosphatase 1, regulatory subunit 15A (PPP1R15A) | 0.105 |
| Heparin-binding EGF-like growth factor (HBEGF) | 0.094 |
| Immediate early response 3 (IER3) | 0.094 |
| FBJ murine osteosarcoma viral oncogene homolog B (FOSB) | 0.094 |
| Jun oncogene (JUN) | 0.090 |
| Brain cytoplasmic RNA 1, (BCYRN1) | 0.078 |
| Tumor necrosis factor α-induced protein 3 (TNFAIP3) | 0.071 |
| Kruppel-like factor 6 (KLF6) | 0.070 |
| Basic helix-loop-helix domain (BHLHB2) | 0.067 |
| Angiopoietin-like 4 (ANGPTL4) | 0.059 |
| Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) | 0.058 |
| AXIN1-up-regulated 1 (AXUD1) | 0.054 |
| Nuclear receptor subfamily 4, group A, member 3 (NR4A3) | 0.052 |
| Myeloid cell leukemia sequence 1 (BCL2-related) (MCL1) | 0.045 |
| Chromosome 2 open reading frame 26 (c2orf26) | 0.040 |
| Pim-3 oncogene (PIM3) | 0.031 |
| RNA, 7SK, nuclear (RN7SK) | 0.030 |
| Baculoviral IAP repeat-containing 3 (BIRC3) | 0.025 |
| Cysteine-rich, angiogenic inducer, 61 (CYR61) | 0.014 |
| GTP-binding protein overexpressed in skeletal muscle (GEM) | 0.013 |
| Tribbles homolog 1 (TRIB1) | 0.011 |
| Nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, ζ (NFKBIZ) | 0.010 |
| Down syndrome critical region gene 1 (DSCR1) | 0.010 |
| RAS, dexamethasone-induced 1 (RASD1) | 0.007 |
| Nuclear factor, interleukin-3-regulated (NFIL3) | 0.002 |
| Unknown Function | |
| Hypothetical protein LOC387763 | 0.041 |